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KMID : 0374019900130040301
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Ewha Medical Journal
1990 Volume.13 No. 4 p.301 ~ p.306
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The Experimental Study on the Effect of Radiation and Cis-Dichlorodiammineplatinum(Ⅱ) in Rat Skin
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Abstract
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The interaction of Cis-dichlorodiammineplatinum(II)(Cis-DDP) with irradiation may beimportant in the clinical settings for which this drug is currently used.
Since the skin is a major tissue for the uptake of Cis-DDP and its uptake level persists for several days, experiments were designed to evaluate the potential of Cis-DDP for enhancing the damage of the irradiated skin in rats.
For experiments, 42 rats were used and radiation dose was 30Gy in single fraction and the dose of Cis-DDP was 2.5mg/kg. The results of these experiments suggest that a Cis-DDP dose of 2.5mg/kg produces no increase skin damage when the drug was administered IP 30min before, or 15min after irradiation.
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